Thalassemia mice
Web5 Oct 2024 · Thalassemia (TH) mice were heterozygous β-globin knockout mice (Hbb th3/+ mice) on C57BL/6 background that were obtained from Mahidol University, Thailand. Citation 30 Wild-type (WT) C57BL/6 mice were purchased from the National Laboratory Animal Center, Nakhornpathom, Thailand. The iron-overload model was performed by oral … Web2 Aug 2024 · The generation of human beta-globin transgenic mice in a beta(IVS-2-654)-thalassemia mouse mediated with lentiviral vectors provides a useful model and offers an …
Thalassemia mice
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Web13 Apr 2024 · Hu Y, Gao X, Zhao Y, Liu S, Luo K, Fu X, Li J, Sheng J, Tian Y, Fan Y. Flavonoids in Amomum tsaoko Crevost et Lemarie Ameliorate Loperamide-Induced Constipation in Mice by Regulating Gut Microbiota and Related Metabolites. Web4 Aug 2024 · The enzyme pyruvate kinase (PK) has recently become of interest in thalassemia. Preclinical studies on PK-deficient mice have indicated that the metabolic disturbance in PK deficiency alters not only the survival of RBCs but also the maturation of erythroid progenitors, resulting in ineffective erythropoiesis.
Web1 Mar 2015 · Mice heterozygous for this deletion (Th3/+), generated by crossing with healthy mice, are viable but exhibit anomalies in RBC size and shape, chronic anemia and … Web1 Jun 2024 · Notably, the survival rate of gene-edited heterozygous β654 mice increased significantly, and liveborn homozygous β654 mice were observed. Our study …
Web23 Nov 2024 · A Severe Mouse Model of Alpha-Thalassemia to Study Abnormal Iron Metabolism and Erythropoiesis, Hematopoietic Stem Cell Behavior and Development of a … WebFor example, co-inheritance of α-thalassemia in β-thlassemia/Hb E is associated with milder clinical symptom whereas co-inheritance of triplicated α-globin gene leads to more severe …
Web22 May 2007 · These mice mimic the human α-thalassemic conditions and can be used as preclinical models for fetal gene therapy. We tested a lentiviral vector containing the HS 2, …
Web23 Feb 2024 · This mouse model is most akin to human thalassemia intermedia, as these mice do not require blood transfusions. The animals, both male and female, were housed … extension for pandWebBromodomain- and extra-terminal domain (BET) proteins are epigenetic reader proteins that regulate transcription of their target genes by binding to acetylated histone side chains. Small molecule inhibitors, such as I-BET151, have anti-inflammatory properties in fibroblast-like synoviocytes (FLS) and in animal models of arthritis. Here, we investigated whether … buckboard\\u0027s yyWeb23 Mar 2024 · In their mouse model of thalassemia major and thalassemia minor, Libani et al. demonstrated a disproportionate percentage of erythroid cells remaining in S phase with an immature erythroblast morphology. When treated with an oral Jak2 inhibitor, thalassemic mice experienced marked reduction in spleen size and a decreased ratio of immature to … buckboard under carriageWeb8 Sep 2024 · Université de Sherbrooke. May 2015 - Mar 20243 years 11 months. Sherbrooke, Quebec, Canada. PhD candidate, Dr. Denis Gris Lab. Research: NOD-Like Receptors (NLRs) as endogenous inhibitors of ... extension for outlook emailWeb1 May 2024 · Iron overload induces intestinal-permeability defect (gut leakage), and gut translocation of organismal molecules might enhance systemic inflammation and sepsis … buckboard\u0027s yyWebThis article is published in Blood Cells Molecules and Diseases.The article was published on 2009-01-01. It has received 11 citation(s) till now. The article focuses on the topic(s): Southeast asian & Alpha-thalassemia. extension for overseas taxpayerWeb22 Aug 2007 · Interestingly, among the mice integrated with combined constructs, one homozygous mouse ( Hbb th-4 /Hbb th-4) had been identified, and the 3-week survival rate … extension for paint brush