Spike ferritin nanoparticle platform
WebMar 14, 2024 · SILVER SPRING, MD — Based on recent preclinical study results, the Spike Ferritin Nanoparticle (SpFN) COVID-19 vaccine is showing significant promise. Not only does it elicit a potent immune response, according to Army researchers, it also appears to provide broad protection against SARS-CoV-2 variants of concern as well as other … WebDec 16, 2024 · A SARS-CoV-2 nanoparticle vaccine was designed and administered to NHPs The SpFN vaccine was designed as a ferritin-fusion recombinant protein for expression as a nanoparticle and has been previously described in detail (20). Briefly, the spike protein sequence was derived from the Wuhan-Hu-1 genome sequence (GenBank accession …
Spike ferritin nanoparticle platform
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WebMay 5, 2024 · To fill these gaps, the team recently developed a SARS-CoV-2 sub-unit vaccine based on the ferritin nanoparticle platform that displays a pre-fusion stabilized viral spike … WebThe first report of the use of ferritin nanoparticles as a vaccine platform demonstrated that influenza virus ... Jagodzinski, L.L.; Paquin-Proulx, D.; Gromowski, G.D.; Swafford, I.; Ganesh, A.; et al. A SARS-CoV-2 spike ferritin nanoparticle vaccine protects hamsters against Alpha and Beta virus variant challenge. NPJ Vaccines 2024, 6 ...
WebWe evaluated whether a spike ferritin nanoparticle vaccine (SpFN), adjuvanted with the Army Liposomal Formulation QS21 (ALFQ), conferred protection against the B.1.1.7 and B.1.351 VOCs in Syrian ... WebJan 27, 2024 · Ferritin is an attractive nanoparticle platform for production of vaccines, and ferritin-based vaccines have been investigated in humans in two separate clinical trials. …
WebEfficacy of a Broadly Neutralizing SARS-CoV-2 Ferritin Nanoparticle Vaccine in Nonhuman Pr ; This article is a Preprint. Preprints are preliminary research reports that have not been certified by peer review. They should not be relied on to guide clinical practice or health-related behavior and should not be reported in news media as ... WebNational Center for Biotechnology Information
WebDec 16, 2024 · A SARS-CoV-2 nanoparticle vaccine was designed and administered to NHPs The SpFN vaccine was designed as a ferritin-fusion recombinant protein for expression …
WebThe “Spike Ferritin Nanoparticle” (SpFN) vaccine employs the common protein ferritin in the form of a soccer ball-shaped “platform”. The platform has 24 “faces” onto which are … horloge tournesolWebFeb 1, 2024 · Ferritin nanoparticle (NP) is an attractive protein nanoplatform for in vivo antigen delivery, presentation and immune stimulation.10, 11, 12, 13 Ferritin NP is self … loss aversion effectWebMar 2, 2024 · Development of Spike Receptor-Binding Domain Nanoparticles as a Vaccine Candidate against SARS-CoV-2 Infection in Ferrets - PMC Back to Top Skip to main content An official website of the United States government Here's how you know The .gov means it’s official. Federal government websites often end in .gov or .mil. loss aversion in video gamesWebMar 18, 2024 · The spike protein is displayed as a multivalent array (8 copies of the antigen) on the ferritin nanoparticle. The antigen, Spike protein-ferritin nanoparticle (SpFN) was … loss avoidance measures sandbags and pumpsWebDec 22, 2024 · “The Spike Ferritin Nanoparticle platform is designed to protect against an array of SARS-CoV-2 variants and SARS-origin variants but was not tested on the Omicron … horloge time timerWebJan 5, 2024 · Spike ferritin nanoparticles can be expressed in mammalian cell culture and purified to homogeneity. (A) Scheme for expressing and purifying spike ferritin … horloge titaniumWebAug 28, 2024 · Ferritin is an attractive nanoparticle platform for production of vaccines and ferritin-based vaccines have been investigated in humans in two separate clinical trials. … loss aversion insurance uptake